| Molecular Formula | C26H42NNaO6 |
| Physical and Chemical Properties | Chemical properties This product is a mixture of sodium taurocholate and sodium glycinate extracted from pig bile and cow bile. It is brownish yellow or light yellow powder, with fresh bile and smelly, and the taste is bitter and sweet. Soluble in water, ethanol, insoluble in ether. It is hygroscopic and deliquescent in the air. |
| Use | Use for long-term drainage of biliary fistula in patients to supplement the lack of bile; Also for fat indigestion, chronic cholecystitis and other patients. No adverse reaction. General bile duct obstruction is contraindicated to prevent increased biliary pressure. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
introduction
Bile salts are the main organic components found in bile. They allow the body to excrete cholesterol and potentially toxic compounds such as bilirubin and drug metabolites. Bile salts are synthesized in liver cells called liver cells, then stored in the gallbladder and secreted to the first part of the small intestine. They are then reabsorbed and returned to the liver, where they are recycled and used by the body again.
action
Bile salts are components of bile, which can mix fat with water, electrolytes and other organic molecules found in bile. Bile needs bile salts to break down fat and prevent it from crystallizing. These salts are naturally produced by our bodies, but some people choose to use bile salt supplements to improve specific health conditions.
production method
Preparation of API
method 1. using pig cholate or calcium cholate mother liquor as raw material
preparation of crude cholic acid take pig cholate or calcium cholate mother liquor, add hydrochloric acid to adjust the pH3-3.5, precipitate precipitate, stand for 12-18h, remove the upper layer of water, wash the precipitate with water until nearly neutral, dry under reduced pressure for 4-5h to obtain crude cholic acid.
pig cholate or calcium cholate mother liquor [HCl, pH3]& rarr; crude cholic acid
preparation of sodium cholate finished product crude cholic acid is taken, dissolved by 6 times the amount of 95% ethanol, adjusted by 400g/L sodium hydroxide solution, pH8-9 by 200g/L activated carbon, heated for 1h, filtered while hot to obtain sodium cholate solution. Concentration, drying at 60 ℃, ball milling, sieving, sodium cholate finished product.
crude cholic acid [ethanol, NaOH]& rarr; Alkaline ethanol solution [activated carbon] & rarr; Sodium cholate solution & rarr; Sodium cholate
method 2. using fresh cow (or sheep, pig) bile as raw material
take fresh cow (or sheep, pig) bile, filter through double-layer gauze, spray dry, add more than 3.5 times the amount of 90% ethanol reflux extraction, filtration, concentration, drying, grinding, sodium cholate finished product.
cattle (sheep, pigs) bile [filtration, drying] & rarr;[extraction] & rarr;[ethanol] [filtration, concentration] & rarr;[drying, milling] sodium cholate finished product
Sodium Cholate Tablets (Sugar-coated Tablets)
preparation (calculated according to the raw materials of 100,000 tablets) wetting dextrin with 20%-30% ethanol and granulating through 10-mesh iron wire sieve. Drying at about 70 ℃, the whole particles are sieved by 12-mesh iron wire, and the fine powder is sieved by 30-mesh sieve to obtain blank dextrin particles. Take 20kg of dextrin blank particles, 10kg of sodium cholate and 0.3kg of magnesium stearate, mix well, sift through 8 mesh once, fully stir well, press the chip core, and coat after the content is qualified. Wrap the chip core several times with single syrup and talcum powder until the chip is not wrapped at the edge, then wrap the isolation layer 2-3 times with 100-150g/L zein ethanol solution, wrap the chip round with glue powder, syrup and talcum powder, wrap the chip with iron oxide syrup until smooth and delicate, polish, cool and dry, and prepare sodium cholate sugar-coated tablets.
dextrin [ethanol] & rarr;[granulation, whole granule] dextrin blank granule [sodium cholate, magnesium stearate] & rarr;[sieving] core [coating] & rarr;[polishing, drying] sodium cholate sugar-coated tablets
this product is a sugar-coated tablet, which shows light yellow or light brown after removing the coating, with fresh bile and bitter taste.